Feasibility and dose-optimization clinical trial of local immunotherapy for solid tumors in canine cancer patients
The primary goal of this research study is to test whether it is safe and feasible to treat tumors by injecting them with a certain type of immunotherapy called T-cell …
A dose-finding study of Paccal Vet in cats with spontaneous solid tumors
No chemotherapies have been FDA-approved for use in cats despite a growing need for such therapies. Paclitaxel (Taxol®) is one of the most effective anticancer agents used in human cancer therapy today, …
Post-operative Paccal Vet for the treatment of canine splenic hemangiosarcoma
Hemangiosarcoma (HSA) is a highly aggressive and malignant vascular tumor occurring most commonly in dogs. Dogs with splenic hemangiosarcoma have a poor prognosis, with fewer than 20% of dogs surviving …
Perspectives on implementing veterinary clinical studies committees
To address the limitations of traditional IACUC review of clinical research studies involving client-owned animals, the AVMA issued a policy describing the use of a veterinary clinical studies committee (VCSC), …
Perioperative and intercalating gefitinib for the treatment of canine osteosarcoma
Osteosarcoma is an aggressive and highly metastatic cancer in both dogs and humans. Gefitinib, a small molecule receptor tyrosine kinase inhibitor that targets Epidermal Growth Factor Receptor (EGFR), approved as …
A preclinical feasibility study evaluating the use of Deep CIVO, a novel intra-tumoral micro-injection device, in canine patients
This is a multi-site prospective 6-9 patient escalation study with 3 canine patients per group, each group having progressively more difficult to access tumors that measure >5cm in diameter. The …
Recommendations for Ethical Review of Veterinary Clinical Trials
Ethical review of both human and animal research is critical to ensuring that studies are conducted with due regard to the welfare and safety of enrolled subjects and to the …